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C57BL/6（老齡鼠）
品系描述：在25-90周齡之間的C57BL/6J的雄性和雌性小鼠。
應(yīng)用領(lǐng)域：應(yīng)用于免疫學(xué)、癌癥、長(zhǎng)壽基因和生物標(biāo)記物等領(lǐng)域的研究。C57BL/6J 是使用最廣泛的近交品系，也是第一個(gè)被全基因組測(cè)序的小鼠品系。C57BL/6J 小鼠對(duì)聽(tīng)源性驚厥具有抗性，骨密度相對(duì)較低，并會(huì)發(fā)展出年齡相關(guān)的聽(tīng)力喪失。它們也對(duì)飲食誘導(dǎo)的肥胖、II 型糖尿病和動(dòng)脈粥樣硬化易感。它們常被用于神經(jīng)退行性疾病和骨密度相關(guān)的研究。
長(zhǎng)期對(duì)C57BL/6J小鼠進(jìn)行的研究揭示，老齡鼠易發(fā)多種病變，包括但不限于腎病、腎小球腎炎、嗜酸性巨噬細(xì)胞肺炎、膿腫、小鼠潰瘍性皮炎、心肌病、脂肪肝以及淋巴結(jié)病變等。同時(shí)，老齡C57BL/6J小鼠還常出現(xiàn)生殖系統(tǒng)的萎縮現(xiàn)象，如睪丸萎縮、卵巢萎縮及卵巢囊腫，以及垂體囊腫、腎上腺色素沉積等內(nèi)分泌系統(tǒng)異常。此外，淋巴瘤也是老齡C57BL/6J小鼠中較為常見(jiàn)的腫瘤類(lèi)型。這些病變的發(fā)現(xiàn)和研究，為人體衰老及相關(guān)疾病的研究提供了寶貴的動(dòng)物模型應(yīng)用經(jīng)驗(yàn)。
使用卡文斯C57BL/6J老齡鼠發(fā)表文獻(xiàn)
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